|Thursday 05 December 2019
Thursday 05 December 2019
Network science for cortical circuits: specificity versus regularity
|When one thinks of the brain – networks of connected neurons and connected brain regions immediately comes to mind. Indeed, already in 1949, Donald Hebb suggested that the activity of connected cell assemblies underlie the engram, proposing biological mechanism for forming such assemblies. Hebb’s idea was recently validated by a set of ingenious optogenetic studies, showing that memory is indeed embedded in the activity of local microcircuits. But what is the anatomical structure of these networks? In particular, of local cortical microcircuits? This question is intensely studies using new experimental and theoretical approaches. From large-scale EM (“connectomics”) combined with machine-learning methods to the development of theoretical approaches to characterize the connectivity of local cortical microcircuits, using graph theory and mathematical topology. Multi-patch recordings in vitro from brain slices provided a wealth of new insights on the structure of cortical circuits.
One key question is “what are the principles that govern network structure in cortical microcircuits? are the cell-to-cell connections highly specific or, alternatively, do these connections obey certain general rules?". This is the leading question in this upcoming EITN meeting, which will bring together renowned experts in what could be called “Network Microcircuit Science”. In this meeting we will focus on:
(i) What is known experimentally about the connectivity of local cortical circuits in both rodents and human?
(ii) How to best analyze the “big data”-based cortical microcircuit topology?
and (iii) Could we already extract, at these early times of “Network Neuroscience” the principles (specific or regular) that govern cortical microcircuit topology?
Preliminary list of speakers :
- Idan Segev (The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Israel)
- Moritz Helmstaedter (Max Planck Institute for Brain Research, Frankfurt)
- Huib Mansvelder (Vrije Universiteit Amsterdam)
- Christiaan PJ de Kock (Vrije Universiteit Amsterdam)
- Rodrigo Perin (EPFL, Lausanne)
- Kathryn Hess (EPFL, Lausanne)
- Jörg Geiger (Charité – Universitätsmedizin Berlin)
- John Beggs (Indiana University Bloomington)
- Javier Defelipe (Cajal Institute, Madrid)
- Nuno da Costa (Allen Institute for Brain Sciences, Seattle)
The registration is free however mandatory due to a limited number of places.
Alain Destexhe (CNRS) and Idan Segev (HUJI)
Espace vocation République
22 rue René Boulanger
The closest subway station is "République" (lines 3, 5, 8, 9, 11)